Prof. Winer of Bethesda spoke on this important topic, presenting interesting
data on innovative treatment options. In particular, she discussed congenital
autoimmune forms of hypoparathyroidism, of which Autoimmune Polyglandu-
lar Syndrome, also called APS-1, is a representative example. Patients affected
with this form exhibit the classic
triad of mucocutaneous candidi-
asis, hypoparathyroidism, and
Addison’s Disease in addition to
deficits affecting other vital or-
gans which determine onset of hypothyroidism, Type
1 diabetes, and gonadal deficit. Treatment of these pa-
tients is complex, since the “treatment window” is
very narrow. These patients need high doses of PTH,
frequent IV administrations of calcium and high doses
of calcitriol, although the complications of such treat-
ment can include nephrocalcinosis and hypercalciuria.
Maintaining the calcium balance is, obviously, a central issue in management of such patients.
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To find answers to these and other interesting queries and for more in-depth in-
formation, go to egister at the site to access the
multimedia material.
Karen K. Winer
Bethesda - USA
Resistant Hypoparathyroidism
How can we deal with and resolve these problems?
Are there efficacious, safe treatment protocols for these patients?